By analyzing the aortic tissue, we found that FOXO4-DRI treatment significantly increased the expression levels of Ki-67 and Lamin B, while reducing the expression of P21, P16, and -H2AX, similar to the results obtained from naturally aged mice (Figure 2A)
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Some types of brain injury (stroke, traumatic injuries, heavy metal toxicity), brain disease (Parkinsons, Alzheimers, MS), and brain disorders (schizophrenia, depression, sleep disorders), affect memory and cognitive function and may be accompanied by oxidative stress